PhD in microalgal biotechnology

[UK] The aim of the work is to develop Chlamydomonas reinhardtii as an effective cell factory. We will express genes encoding high-value proteins, and enzymes that generate high-value chemicals, in the chloroplast of transformed strains. Some of the background to this project can be viewed in the following recent papers:

  1. Zedler, J.A.Z., Gangl, D., Hamberger, B. , Purton, S., and Robinson, C. (2014). Stable Expression of a Bifunctional Diterpene Synthase in the Chloroplast of Chlamydomonas reinhardtii. J. Appl. Phycol. DOI 10.1007/s10811-014-0504-2.
  2. Gangl, D., Zedler, J.A.Z., Włodarczyk, A., Jensen, P-E., Purton, S., and Robinson, C. (2015). Expression and membrane-targeting of an active plant Cytochrome P450 in the Chlamydomonas reinhardtii chloroplast genome. Phytochemistry 110:22-28.
  3. Gangl, D., Zedler, J.A.Z., Rajakumar, P.D., Martinez, E.M.R., Riseley, A., Włodarczyk, A., Purton, S., Sakuragi, Y., Howe, C.J., Jensen, P.E. and Robinson, C. (2015). Biotechnological exploitation of microalgae. J. Exp. Bot. 66, 6975-6990.
  4. Zedler, J.A.Z., Gangl, D., Guerra, T., Santos, E., Verdelho, V.V. and Robinson, C. (2016). Pilot-scale cultivation of wall deficient transgenic Chlamydomonas reinhardtii strains expressing recombinant proteins in the chloroplast. Appl. Microbiol. Biotechnol. (in press).

This 3-year PhD is funded by the University of Kent. Applicants should have a BSc in biology or a related discipline, and be proficient at English.

For further information contact the PI, Professor Colin Robinson, at [email protected]

 

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